Endoscopic in vivo cellular imaging of superficial squamous cell carcinoma of the head and neck by using an integrated endocytoscopy system (with video) - 17/07/13
Abstract |
Background |
Recently, some patients have been found to have superficial squamous cell carcinoma (SCC) of the head and neck region during GI endoscopy; however, endoscopic biopsy from a lesion in the head and neck region is troublesome. An endocytoscopy system has been reported to enable optical biopsy of an esophageal lesion.
Objective |
To evaluate the feasibility of in vivo cellular imaging with an integrated endocytoscopy system for patients with superficial SCC of the head and neck.
Design |
Experimental pilot study.
Setting |
University hospital.
Patients |
This study involved 12 patients who were found to have superficial SCC of the head and neck during GI endoscopy.
Intervention |
Endocytoscopic images were taken of each lesion and of the surrounding mucosa. The images were later reviewed by 1 pathologist and 2 endoscopists who were unaware of any other findings.
Main Outcome Measurements |
Correlation between endocytoscopy diagnosis and histologic diagnosis.
Results |
Adequate endocytoscopic images could be obtained in 11 of the 12 patients (15 of 16 lesions). For endocytoscopic images of 15 lesions and 12 areas of surrounding mucosa, the overall accuracy of endocytoscopic diagnosis in differentiating between nonmalignant and malignant histopathology by the pathologist, endoscopist 1, and endoscopist 2 were 96%, 96%, and 96%, respectively. The kappa value for interobserver agreement was 0.77.
Limitations |
Single-center experience, small number of patients.
Conclusion |
An endocytoscopy system has the potential to be used as an optical biopsy for superficial head and neck lesions.
El texto completo de este artículo está disponible en PDF.Abbreviations : APC, ECA, NBI, SCC
Esquema
| DISCLOSURE: All authors disclosed no financial relationships relevant to this publication. |
Vol 78 - N° 2
P. 351-358 - août 2013 Regresar al número
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Bienvenido a EM-consulte, la referencia de los profesionales de la salud.
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